From MangaHelpers:Since the Edo periods of Japan, gladiator arenas exist in certain areas. In these arenas, wealthy business owners and merchants hire gladiators to fight in unarmed combat where winner takes all. Tokita Ouma, nicknamed "Ashura", joins these arenas and devastates his opponents.
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Project SHaDe summary:
In a world that curses humans to morph into beasts, beast hunter Kafka must uncover his elusive past, and receive a revelation that will either bring him to despair or legend.